Simulation studies as designed experiments: the comparison of penalized regression models in the "large p, small n" setting.

Permutation tests for the equality of group distributions null hypothesis (using distance component analysis [10] - see the “Data analysis” subsection on Methods for details) presented in Table 1 , confirm that the group differences are highly significant (p-value ) for the number of features, correlation, and sample size parameters (note the high values of the observed test statistics), but non-significant for saturation, and marginally significant for the signal-to-noise parameter.

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