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Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops.

Springerplus · 2014 · PMC4190280 · PMID 25332850

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an increasing trendno p-value reported
” In the past few decades there has been an increasing trend towards large trials, involving many subjects, with numerous authors funded by large institutions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.