highly significantP < 0.001
In the study of Gabrielsen et al ., the mean size of EC in patients with and without BM was 8.6 ± 2.8 cm and 5.1 ± 2.5 cm, respectively, suggesting a highly significant correlation between increased EC size and BM risk ( P < 0.001).[ 9 ] On the basis of this study, Go et al . concluded, “preoperative neuroimaging is not indicated for routine staging of patients with EC except large tumors (>8 cm).”[ 10 , 11 ] However, in our study, the mean EC size in patients with BM was 5.8 ± 2.9 cm, suggesting that BM can occur in association with EC lesions that are smaller than those generally estimated.