Metformin reduces thyroid cancer risk in Taiwanese patients with type 2 diabetes.

PLoS One · 2014 · PMC4193839 · PMID 25303400

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an increasing trendno p-value reported

With regards to thyroid cancer, there has been an increasing trend of its incidence over the past decades worldwide; and this has been ascribed to the increasing prevalence of insulin resistance [10] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.