Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation.

J Cell Mol Med · 2014 · PMC4196662 · PMID 25109373

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highly significantno p-value reported

Next, we found that both Aβf and Aβf-CM caused a time-dependent reduction in the release of ChAT, levels of which peaked at 19–20 DOD, but then gradually decreased to as low as one-fourth of its peak in vitro levels, while the secreted levels of the ACh-degrading enzyme BuChE showed a highly significant increase.

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