Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms.

PLoS One · 2014 · PMC4196930 · PMID 25313689

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highly significantno p-value reported

Conclusions Analysis of every available phenotypically characterized B-HIV Env sequence in the Los Alamos HIV Database revealed a highly significant association between covariant charged amino acids at Env positions 322/440 and coreceptor usage.

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