Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells.

In this experimental background, we found that Tax-expression when induced by Zn, but not when induced by Cd, provoked highly significant apoptotic death at otherwise non-cytotoxic concentrations for each divalent cation-alone (Figure 1 ).

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