In contrast, there was a highly significant correlation between the response to CDK9 inhibition and MYC mRNA expression ( Fig. 4A,B ; Supplemental Table 4), an effect confirmed by immunoblotting for MYC protein ( Fig. 4C ; Supplemental Fig. 4C).
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CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.
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