Barely Significant
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How structure defines affinity in protein-protein interactions.

PLoS One · 2014 · PMC4199723 · PMID 25329579

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highly significantno p-value reported
Interestingly, Ala propensity shows an anti-correlation with affinity that is highly significant, indicating that this amino acid, within an interface, cannot provide favorable interactions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.