APC methylation was found to be a significant predictor of PC specific death when both cohorts were combined and was borderline significant in each of the two cohorts when analyzed separately ( Table 2 ) [ 54 ].
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The sentences
In the validation study [ 13 ], microarray data showed that high PITX2 methylation was significantly associated with early recurrence after prostatectomy in univariate analysis, and remained significant also in multivariate analysis together with Gleason score, tumor stage, and surgical margin status, whereas pre-operative PSA showed borderline significance.