Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.

The steady-state NAD + levels showed an increasing trend in mouse livers and muscle after 16 weeks of NR diet, but these steady-state changes after long-term diet were subtle (Supplementary Fig S1A and B).

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Very old Deletor mice, from 23 to 27 months of age, showed a decreasing trend in their skeletal muscle (Fig 1 ), whereas younger mice of 17–21 months showed a variation in their NAD + levels with no clear decrease ( Supplementary Fig S1 ).

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