Investigating the size and dynamics of voltage-gated sodium channel fenestrations.

It is likely that the 4 fenestrations in Nav1.2 and Nav1.4 are differentially sized as a consequence of such amino acid differences between the 4 repeats, but since there may be significant structural differences between eukaryotic and bacterial VGSCs, it is difficult to tell if residues at other positions in the sequence contribute to fenestration bottlenecks in eukaryotic VGSCs or if structural differences contribute to a widening or restriction of the fenestrations in other ways.

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