highly significantP =2.53 × 10 -67
The difference in free energy values between genes with decreased TE in Silvestrol and insensitive genes was highly significant ( P =2.53 × 10 -67 ) and a difference in distribution of ∆G values from genes with increased TE was also notable compared with the insensitive pool ( P =4.25 × 10 -7 ) (Figure 2 a).