The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.

J Exp Med · 2014 · PMC4203955 · PMID 25288399

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a nonsignificant trendno p-value reported

Stimulation of naive B cells with CD40L+IL-4 ±IL-5 resulted in an approximately twofold increase in the generation of CD138 + ASCs in the absence of Bcl6, whereas Bcl6 +/− cells showed a nonsignificant trend toward increased ASC numbers ( Fig. 6, C and D ).

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