A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.

Ann Neurol · 2014 · PMC4204160 · PMID 24853080

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a positive trendno p-value reported

The pooled data in the mild AD cohort failed to reveal an improvement in ADCS-ADL, although there was a positive trend.

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highly significantno p-value reported

This dosing regimen produced a highly significant 68% reduction in deposited Aβ42 accrual in the hippocampus.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.