Mechanical compression insults induce nanoscale changes of membrane-skeleton arrangement which could cause apoptosis and necrosis in dorsal root ganglion neurons.

The incidence of traumatic spinal cord injury (SCI) has presented an increasing trend over the last few decades. 1 ) SCI involves an acute phase of primary injury that causes immediate cell damage and vascular disruption followed by a phase of delayed secondary injury that may last from hours to weeks. 2 ) The primary injury usually involves direct compression of the spinal cord as a result of dislocation of the spinal vertebral motion segments or displaced bone fragments.

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