Impaired endothelium-mesenchymal stem cells cross-talk in systemic sclerosis: a link between vascular and fibrotic features.

Using a tri-dimensional Matrigel system for EC/MSC co-cultures, we showed a highly significant reduction of the ability to form tubular structures when SSc-ECs were cultured with SSc-MSCs, whereas the presence of MSCs (from both patients and HCs) in each condition improved the angiogenic ability of ECs cultured alone.

also in 132,142 other papers