Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.

In the open field test, we observed a highly significant novelty-induced hyperactivity in an unfamiliar environment (p MW (p value for Mann-Whitney test) <0.0006; Figure 4A ), persistent during the entire test (effect of genotype p = 0.0002; 2-way ANOVA, Figure 4B ) and most prominent in interval 3, 5 and 10 (p Bonf (p values for Bonferroni post test) <0.01, <0.05 and <0.05, respectively;).

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