It may be significant that the relative mean changes in chemical shift for HMG-D, ZmHMGB1, and HMGB1 (0.028, 0.050, and 0.045 ppm, respectively) increase with increasing tail length (12, 34, and 30 residues, respectively), presumably reflecting increasing affinity of the tails.
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Structural insights into the mechanism of negative regulation of single-box high mobility group proteins by the acidic tail domain.
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