Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.

Lipids Health Dis · 2014 · PMC4210508 · PMID 25311932

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marginally significantno p-value reported

Analysis of the gene–environment interaction revealed that body mass index (BMI) was a significant effect modifier for APOA5 T − 1131C (rs662799) and a marginally significant effect modifier for APOA5 T/C (rs2266788), with the interaction between BMI ≥30 and individuals with at least one minor allele of each genotype of OR 10.43 (95% CI: 1.29–84.19) and 3.36 (0.87–13.01), respectively.

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marginal significanceno p-value reported

However, their marginal significance could have been detected as a result of a type I error, which necessitates further investigation with sufficiently larger sample sizes.

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