Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA.

Is this difference in SNP frequency simply attributable to adaptive purging of deleterious exonic SNPs? If so, it becomes necessary to argue that approximately half of all single nucleotide changes across the human exome (the vast majority of which—including synonymous SNPs—would be of no known functional consequence) were instead highly significant, and that a sizeable number of these (approximately 50%) have been expunged (e.g. due to premature death or decreased fitness).

also in 132,142 other papers