Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study.

PLoS One · 2014 · PMC4211741 · PMID 25350130

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highly significantno p-value reported

Statistically significant, non-linear dose-response relationships with reduced tissue infectibility were found for one TFV compartment and four TFVdp compartments; the dose-response relationships were highly significant for TFVdp in whole rectal tissue, CD4 + MMC , CD4 − MMC and Total MMC compartments.

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