However, advancements of the numerous passive immunizations in the last decade [ 49 ] that resulted in more or less significant increase in the resistance to PrP Sc , including the prolongation of the incubation period and the lifespan of treated animals, have been compromised with their possible neurotoxic effects [ 55 , 85 ].
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Prion protein-specific antibodies-development, modes of action and therapeutics application.
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