This is a highly significant issue, as only a handful of lncRNAs transcription units with regulatory roles have been identified in S. cerevisiae despite the fact that several thousand lncRNAs are transcribed across the genome ( Hongay et al. 2006 ; Camblong et al. 2007 , 2009 ; Houseley et al. 2008 ; Castelnuovo et al. 2013 ).
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ATP-dependent chromatin remodeling shapes the long noncoding RNA landscape.
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