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Quality of medicines in Canada: a retrospective review of risk communication documents (2005-2013).

BMJ Open · 2014 · PMC4216865 · PMID 25361839

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an increasing trendno p-value reported
Our observations of defective medicines recalls over nine consecutive years, from 2005 to 2013, have shown that the recall of substandard medicines is an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.