Omitting wobble pairings, we found a highly significant correlation between mRNA codon demand and corresponding tRNA anticodon availability in both tissues and at all developmental stages (Spearman-rank test [ρ] from 0.64 to 0.76, all P < 0.001), ( Fig. 4C , left; Supplemental Fig. 12).
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High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface.
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