Gene ontology (GO) analysis of H3S28ph targets revealed a highly significant enrichment for genes with molecular functions in signaling, transcriptional control, and nucleoside/nucleotide binding, cellular metabolism regulation, intracellular transport, and cell death (Supplemental Fig. 3; Supplemental Table 4).
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H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress.
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