Altered protease-activated receptor-1 expression and signaling in a malignant pleural mesothelioma cell line, NCI-H28, with homozygous deletion of the β-catenin gene.

PLoS One · 2014 · PMC4218765 · PMID 25364818

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highly significantno p-value reported

Since the NCI-H28 cell line is only one among other MPM cell lines examined, which shows a highly significant increase of PAR 1 expression compared to Met-5A and human primary mesothelial cells, we may speculate that β-catenin indirectly modulates PAR 1 expression at transcriptional level.

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