Barely Significant
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Therapeutic effect of vagus nerve stimulation on depressive-like behavior, hyperglycemia and insulin receptor expression in Zucker fatty rats.

PLoS One · 2014 · PMC4218831 · PMID 25365428

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highly significantno p-value reported
The increasing burden of T2D and major depressive disorder makes the search for an extended understanding of etiology and for the development of additional treatments highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.