Barely Significant
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Changes in methylation patterns of kiss1 and kiss1r gene promoters across puberty.

Genet Epigenet · 2013 · PMC4222338 · PMID 25512707

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highly significantno p-value reported
Both Kiss1 and Kiss1r showed highly significant puberty-specific differential promoter methylation patterns.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.