Transcriptomic changes triggered by hypoxia: evidence for HIF-1α-independent, [Na+]i/[K+]i-mediated, excitation-transcription coupling.

Significantly, we observed highly significant (p<4×10 −9 ) and positive (R 2 >0.80) correlations between levels of differentially-expressed transcripts identified in the presence of ouabain and K + -free medium ( Fig. 4 ).

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