MTX-4 rats (Group C) demonstrated an additional decrease in jejunal villus height (321±20 vs 396±24 μm, p<0.05) compared to MTX-2 animals as well as a trend toward additional decrease in ileal villus height and crypt depth; however, this trend was not significantly significant.
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The role of Wnt/β-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat.
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