Application of a new parameter in the 6-minute walk test for manifold analysis of exercise capacity in patients with COPD.

plement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY-NC Introduction Chronic obstructive pulmonary disease (COPD) is recognized as a serious global health burden with an increasing trend of incidence, estimated to represent the third most common cause of death worldwide by 2020. 1 Patients with COPD experience chronic cough, sputum production, and dyspnea at rest and during daily activities. 2 , 3 As the disease progresses, dyspnea on exertion limits physical activity and is associated with higher mortality. 4 In addition, reductions in physical activity have been observed even in mild cases. 5 Accordingly, an assessment of the limitations of physical activity is important for clinical management of patients with COPD.

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