Specific modifications of histone tails, but not DNA methylation, mirror the temporal variation of mammalian recombination hotspots.

Using methylation-associated single nucleotide polymorphisms (mSNPs) as a surrogate for germline DNA methylation, highly significant positive correlations between mSNP densities and recombination rates at both global- (>500-kb windows) and fine-scale (the proportions of nucleotides belonging to recombination hotspots) were shown ( Sigurdsson et al. 2009 ).

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