Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives.

In contrast to 89 Zr-huJ591 (Figure 3 C), very minimal to no activity is present in the lung and heart in both 89 Zr-antibody fragments, proof that the circulating probes were eliminated faster than the intact mAb. Quantification of tumor uptake is presented in Figure 4 A (SI Table 6 in the Supporting Information ), which displays an increasing trend in tumor uptake for all three radiotracers.

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