Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates.

J Int AIDS Soc · 2014 · PMC4225392 · PMID 25397454

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highly significantno p-value reported

In vivo analyses in HIV-infected humanized mice demonstrated highly significant antiviral effects of Tre recombinase [ 2 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.