These results suggest that in the synergistic transcriptional effects of P-TEFb and SEC on the activity of RNA polymerase, the recruitment of SEC to the HIV promoter is highly significant for enhancing viral transcription.
← all excerpts
A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.
1
—
—