Correlation of phenotypic profiles using targeted proteomics identifies mycobacterial esx-1 substrates.

This highly significant correlation likely reflects the molecular relationship between EsxA and EsxB; the two are encoded in an operon, directly interact and form a 1:1 dimer, and require each other for stability. 8 , 81 , 82 Interestingly, the EspJ and EspK substrates shared genetic requirements for export into the CF.

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