Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression.

ESR1 enrichment within disease/trait-associated regions There was highly significant enrichment of ESR1 binding sites within genomic regions associated with breast cancer, height, MS and prostate cancer, which was consistent over multiple datasets and increased in magnitude for binding sites shared between multiple datasets (Additional file 1 : Table S5, Table 1 ).

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