The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input.

J Physiol · 2014 · PMC4229351 · PMID 24879873

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failed to reach significanceno p-value reported

It is likely that the effect of yohimbine on C- versus A-nociceptor evoked withdrawals failed to reach significance (data not shown) as a result of the inherent underestimation of the full effect of yohimbine on C-nociceptor withdrawal thresholds caused by the imposed temperature cut-off (55°C).

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