High-dimensional analysis of the aging immune system: verification of age-associated differences in immune signaling responses in healthy donors.

Age associations which reached statistical significance in the current study cohort may have failed to reach significance in the prior cohort for several possible reasons: 1) there was lower power for detecting significant differences in the prior study than in the current study due to sample size differences (Table 1 ), 2) age-associated differences may be more pronounced within a cohort containing only young (<40 yrs) and elderly (>65 yrs) donors than in a cohort in which the majority of the donors are between 40–65 yrs (Figure 1 ), or 3) some of the age-associations identified within the current cohort could be “false positives”.

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