Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus.

In contrast to the neutral expectation, we found that there is highly significant heterogeneity in the ratio of polymorphism to divergence across the five exons of Hmr (Hudson-Kreitman-Aguade test [HKA test; Hudson et al. 1987 ]; p = 0.025; 10,000 simulations performed).

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