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Guidelines adherence in the treatment of patients with newly diagnosed type 2 diabetes: a historical cohort comparing the use of metformin in Quebec pre and post-Canadian Diabetes Association guidelines.

BMC Health Serv Res · 2013 · PMC4231333 · PMID 24160916

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an increasing trendno p-value reported
In addition, when yearly metformin initiation rate was analyzed, we saw an increasing trend since 2007.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.