There was a nonsignificant trend of quicker blood pressure control with SNP over esmolol (21 ± 15 vs. 29 ± 14 min, respectively).[ 33 ] The calcium channel blockers nicardipine and clevidipine have been compared with nitroprusside.
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Treatment with nitroprusside and nitroglycerin were associated with a higher mortality, but this was of borderline significance and likely confounded by bias with regard to choice of agent.[ 38 ] One study by Immink et al . compared labetalol with nitroprusside in their effects on cerebral hemodynamics in the treatment of malignant hypertension.