a decreasing trendP =0.092
We found a decreasing trend in 5-mc (0.84%±0.48% in TRD, 1.25%±0.17% in non-TRD, df =22, P =0.092) and 5-hmc (1.14%±0.59% in TRD, 1.53%±0.43% in non-TRD, df =22, P =0.090) levels in TRD patients, compared to the non-TRD severe patient group.