Quantification and dynamic monitoring of EGFR T790M in plasma cell-free DNA by digital PCR for prognosis of EGFR-TKI treatment in advanced NSCLC.

PLoS One · 2014 · PMC4236040 · PMID 25405807

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a decreasing trendno p-value reported

an increasing trendno p-value reported

Among EGFR-mutant cases, patients with an increasing trend in T790M quantity from pre- to post-EGFR-TKI displayed superior PFS and OS compared with patients with a decreasing trend.

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