The division into the Dact1/3 and Dact2/4 groups was highly significant in the likelihood mapping analysis (92.2%, Figure 2 C) and well supported in the PhyML tree for gnathostome sequences (bootstrap value of 100; Additional file 5 ).
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Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathways.
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