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Soluble toll like receptor 2 (TLR-2) is increased in saliva of children with dental caries.

BMC Oral Health · 2014 · PMC4236648 · PMID 25174416

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an increasing trendno p-value reported
Recent systematic analyses suggest that the incidence of caries exhibits an increasing trend in children aged 2–4 years in the United States [ 2 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.