Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.

Cell Death Dis · 2014 · PMC4237233 · PMID 25299784

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highly significantno p-value reported

Leukemia cells (HL-60 and THP-1) and breast cancer cells (MCF-7) proved most sensitive toward the semi-synthetic analogs, in particular HBA showing highly significant cytotoxic effect. 20 The antiproliferative effects of HBA was further investigated in HL-60, THP-1 and MCF-7 cells in order to get the concentration- and time-dependent IC 50 values.

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