Its synthesis is increased in remodeling of an injured area after a wound 15 , 16 and also its production has an increasing trend in fibrotic diseases 17 , 18 while has a decreasing trend during aging and after a sun exposure. 19 For decades, skin organ culture has successfully been used to study skin ex vivo . 20 Normal human dermal fibroblast cultures can be divided into three phases of (i) primary cultures established by
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Its synthesis is increased in remodeling of an injured area after a wound 15 , 16 and also its production has an increasing trend in fibrotic diseases 17 , 18 while has a decreasing trend during aging and after a sun exposure. 19 For decades, skin organ culture has successfully been used to study skin ex vivo . 20 Normal human dermal fibroblast cultures can be divided into three phases of (i) primary cultures established by enzymatic digestion of the dermis, or by outgrowth of fib